When a bloodstained car connected to two missing girls (Nicole Gilbert and her best friend Kara Palmer) is found abandoned off a local interstate along an isolated lumber town, CBI is called in to help. Upon arrival, Jane locates Kara stabbed to death under the car, but Nicole is nowhere to be found. After searching for her, Nicole turns up at a gas station, covered in blood and holding the murder weapon but has no recollection of what happened. Could she have killed her best friend? Jane, seemingly convinced Nicole is innocent and her memory is just blocked, engineers a situation in which Nicole must relive the terrifying evening. As her memories return and as she helps Jane identify the killer, Lisbon finds herself unintentionally facing him as well, alone.